Nkhani

Odwala omwe ali ndi mild dilated cardiomyopathy (MDCM), kuchuluka kwa mapuloteni okhudzidwa kwambiri a C-reactive (hs-CRP) amalumikizidwa ndi kuchuluka kwa N-terminal brain natriuretic peptide (NT-proBNP) mwa odwala omwe ali ndi mtima wochepa kwambiri (MDCM) .), ngakhale palibe umboni wotsimikizira zotsatira zolosera zokhudzana ndi zotsatira za odwala.Zotsatirazo zidasindikizidwa mu ESC Heart Failure magazine.
Kufufuza kwachidziwitso kwa odwala omwe ali ndi matenda a mtima (DCM) ndi kumanzere kwa ventricular ejection chigawo chochepera 50% chomwe chinaloledwa ku Fuwai Hospital ku Beijing, China kuyambira December 2006 mpaka October 2017.Ofufuzawo ankafuna kufananitsa biomarkers NT-proBNP ndi hs-CRP mwa odwala MDCM ndi odwala DCM.Mu phunziro ili, MDCM inatanthauzidwa ngati kumanzere kwa ventricular end-diastolic diameter index (LVEDDi) ya 33 mm / m2 kapena yochepa mwa amuna ndi 34 mm / m2 mwa akazi.
Okwana 640 anaphatikizidwa pakuwunikaku, pomwe 17% adasankhidwa kukhala ndi MDCM ndipo 83% adasankhidwa kukhala ndi DCM poyambira.Pazonse, 24.8% mwa omwe adatenga nawo gawo anali azimayi.Zaka zapakati za odwalawo zinali zaka 49.
Poyerekeza ndi otsogolera a DCM, odwala a MDCM anali aang'ono, anali ndi kuthamanga kwa magazi, kuchuluka kwa shuga, kuchepa kwa ventricular tachycardia yosasunthika, chiwerengero chapamwamba cha thupi, komanso chipatala chachifupi. Ponena za zizindikiro za mtima, odwala omwe ali ndi MDCM anali otsika kwambiri apakati a NT-proBNP poyerekeza ndi odwala omwe ali ndi DCM (2203 pg / mL vs 1448 pg / mL, motero; P <.001). Ponena za biomarkers, odwala omwe ali ndi MDCM anali otsika kwambiri apakati a NT-proBNP poyerekeza ndi odwala omwe ali ndi mtima DCM (2203 pg / mL vs 1448 pg / mL, motero; P <.001). Что касается сердечных биомаркеров, у пациентов с MDCM pr. Ponena za zizindikiro za mtima, odwala a MDCM anali otsika kwambiri a NT-proBNP poyerekeza ndi odwala DCM (2203 pg / mL vs. 1448 pg / mL, motero; P <0.001).关于心脏生物标志物，与DCM 患者相比，MDCM 患者的NT-proBNP 水平中位数显着降低和（分2m4别1 pm/Pm4.MDCM 患者的NT-proBNP 水平中位数显着降低（分别，与2203 pg/mL 和L0.0 pg/mL 和L0.0 Что касается сердечных биомаркеров, у пациентов с MDCM средний уровень NT-proBNP был значительно ниже по сравнечные биомаркеров, 10 пациентов с пациен 1/20; Pankhani ya biomarkers ya mtima, mayendedwe a NT-proBNP anali otsika kwambiri mwa odwala a MDCM poyerekeza ndi odwala DCM (2203 pg/mL ndi 1448 pg/mL, motero; P <0.001).Mosiyana ndi zimenezi, zikutanthauza kuti ma hs-CRP anali apamwamba kwa odwala MDCM kuposa odwala DCM (3.09 mg / L ndi 2.79 mg / L, motero; P = 0.39).
Pakati pa odwala 282 omwe adatsata ndondomeko ya echocardiographic pakapita miyezi 6 kapena kuposerapo, odwala 7 omwe ali ndi MDCM (11.1%) adapanga DCM, pamene odwala 70 omwe ali ndi DCM (32.0%) anabwerera ku MDCM, monga momwe kusintha kwa LVEDDi kunawonedwa.
Odwala a MDCM oyambirira anali ndi chiopsezo chochepa chophatikizira cha imfa zonse, kuika mtima, ndi kuwerengedwanso chifukwa cha kulephera kwa mtima poyerekeza ndi otsogolera a DCM (adjusted hazard ratio [aHR], 0.63; 95% CI, 0.43-0.93; P = 0.019).
Magawo onse a hs-CRP ndi NT-proBNP adalumikizidwa pawokha ndi mathero ophatikizika pagulu lonse lamaphunziro (hs-CRP, aHR, 1.07; 95% CI, 1.00-1.15 ndi NT-proBNP: aHR , 1.11, 95% CI, 1.02–1.22, p = 0.019).
Pambuyo poyerekezera kuchuluka kwapakati pakati pa MDCM ndi DCM, mgwirizano pakati pa NT-proBNP ndi mapeto ophatikizana unali wogwirizana ndi zomwe zinanenedwa asanafanizire odwala ndi DCM (RR, 1.83; 95% CI, 1.05-3.20; P = 0.034), koma osati odwala omwe ali ndi MDCM (HR, 1.54, 95% CI, 0.76-3.11, P = 0.227).Mosiyana ndi zimenezi, magulu a hs-CRP adakali ogwirizana kwambiri ndi odwala omwe ali ndi MDCM (RR 3.19; 95% CI 1.52-6.66; P = 0.002), koma osati odwala omwe ali ndi DCM (RR 1.04; 95% CI).0,61–1.79;p = 0.88.
Kuchepetsa kwa phunziroli ndikuti phenotype ya odwala imatha kusintha panthawi yotsatiridwa, ngakhale kuti chiwerengero cha anthu omwe anabwereza kubwereza echocardiography chinali chochepa kwambiri, kotero kuti zolosera za kusintha kwa phenotypic sizinafufuzidwe.Kuonjezera apo, chifukwa cha kukula kwachitsanzo cha odwala a MDCM mu phunziroli, zinthu zomwe zingakhale zosokoneza sizinasinthidwe mokwanira mu kufufuza kwa multivariate.
"Baseline hs-CRP idalumikizidwa ndi zotsatira zophatikizana ndi odwala a MDCM asanayambe komanso atatha kusintha ma covariates, pomwe NT-proBNP idangogwirizana ndi zotsatira ku DCM," olemba owerengera amalemba."Kafukufuku wowonjezereka akufunika kuti afufuze zolosera za kusintha kwa ventricular geometry ndi ntchito ya mtima, makamaka kwa odwala omwe ali ndi MDCM, kuti apereke chiwopsezo cholondola."
Kuwulura: Palibe m'modzi mwa olemba kafukufuku amene adanena kuti amagwirizana ndi biotech, mankhwala, ndi/kapena makampani opanga zida.
Feng J, Tian P, Liang L, et al.Zotsatira ndi kufunikira kwachidziwitso cha N-terminal pro-brain natriuretic peptide ndi mapuloteni okhudzidwa kwambiri a C-reactive mu mild and dilated cardiomyopathies.ESC mtima kulephera.Yosindikizidwa pa intaneti pa Marichi 4, 2022 doi: 10.1002/ehf2.13864
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